先天免疫檢查點NLRP12
NLRP12 regulates signaling cascades activated by Toll-like receptors, RIG-I like receptor and cGAS-STING pathway, impacting the production of proinflammatory cytokines and type I IFN. This led us to name NLRP12 an innate immune checkpoint (Cell Host & Microbes, 2019; Journal of Clinical Investigation, 2023). Recently, we have been investigating the role of NLRP12 in the pathogenesis of several inflammatory diseases, including SLE, sepsis, arthritis and vascular stiffness, which are linked to dysregulated NET formation and type I IFN signatures.